Tirzepatide: A new glucagon-like peptide-1 receptor/glucose-dependent insulinotropic peptide receptor dual agonist
10.12092/j.issn.1009-2501.2023.02.014
- Author:
Shifeng ZHAO
1
;
Xiangming SONG
1
;
Jianping YAO
2
Author Information
1. Department of Pharmacy, Huzhou Central Hospital
2. Department of Endocrinology, Huzhou Central Hospital
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1;
glucose-dependent insulinotropic peptide;
obesity;
tirzepatide;
type 2 diabetes
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(2):220-227
- CountryChina
- Language:Chinese
-
Abstract:
Tirzepatide is the first-in-class dual agonist of glucagon-like peptide-1 (GLP-1) receptor and glucose-dependent insulinotropic peptide (GIP) receptor, which plays a variety of physiological effects by imitating natural GLP-1 and GIP. In the completed large phase III series of clinical studies of SURPASS and SURMOUNT, Tirzepatide has demonstrated excellent effects in decreasing glycosylated hemoglobin, reducing weight, improving blood lipid and other metabolic indicators, and is superior to the currently approved GLP-1 receptor agonist. Gastrointestinal reaction is the most common adverse event of the drug, which is generally mild to moderate, and decreases with continuous administration. On May 13, 2022, Tirzepatide was approved for listing by FDA, the current indication is to improve glycemic control of adult patients with type 2 diabetes (T2D) as an adjunct of diet and exercise. In addition to T2D and obesity, there are also extensive and in-depth studies on other metabolic fields. This paper makes a systematic overview of this.
