Research progress of JAK/STAT signaling pathway in the intervention of diabetic microvascular complications
10.12092/j.issn.1009-2501.2023.12.012
- Author:
Tao LI
1
;
Lixia YANG
2
;
Bo GAO
3
;
Qin LI
3
;
Shuang SONG
3
Author Information
1. Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine
2. Gansu Academy of Traditional Chinese Medicine
3. Gansu Health Vocational College
- Publication Type:Journal Article
- Keywords:
diabetic microvascular complications;
JAk/STAT;
traditional Chinese medicine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(12):1415-1421
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic microvascular complications are the main reason for the high mortality of diabetic patients. There is still a great shortage of existing therapeutic drugs, so there is an urgent need for more effective new drugs. Janus kinase/signal transducer and activator of transcription (JAK/STAT) is involved in the progression of diabetic microvascular complications, which can be improved by regulating this pathway. Therefore, this article reviews the progress of JAK/STAT in diabetic microvascular complications (diabetic kidney disease, diabetic retinopathy, diabetic peripheral neuropathy), and summarizes the potential drugs that intervene JAK/ stat to improve diabetic microvascular complications in recent years from three aspects of therapeutic drugs, preclinical drugs, and traditional Chinese medicine, in order to provide ideas for drug development and treatment of diabetic microvascular complications.
