Experimental study on pharmacodynamics of Su Bei Zhi Ke granules (SBZKG) for acute tracheobronchitis
10.12092/j.issn.1009-2501.2024.01.006
- Author:
Hongwei KAN
1
;
Jun TIAN
2
Author Information
1. Yangtze River Delta Center for Drug Evaluation and Inspection of NMPA
2. Anhui Provincial Institute for Food and Drug Inspection and Research
- Publication Type:Journal Article
- Keywords:
acute tracheobronchitis;
antibacterial;
antiviral;
expectorant;
stop cough;
Su Bei Zhi Ke granules
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(1):61-67
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of Su Bei Zhi Ke granules (SBZKG) on acute tracheobronchitis (Syndrome of Wind-cold Attacking Lung). METHODS: Mouse ear swelling experiment and mouse abdominal capillary permeability experiment was used to observe its anti-inflammatory effect. Cough test in mice induced by ammonia water, and phlegm test in rats were used to observe the expectorant and antitussive effects of phenol red test in mice. We used the mortality rate experiment of infected mice to observe its antibacterial and antiviral effects. RESULTS: Compared with the contral group, the large and medium dose groups of SBZKG both reduced mouse auricle swelling (P<0.05) and increased swelling inhibition rate, reducing mouse abdominal capillary permeability (P<0.05, P<0.01). SBZKG can increase the phenol red sputum output in the respiratory tract of mice (P<0.01), prolong the cough incubation period of mice, reduce the number of coughs in mice (P<0.05, P<0.01), and increase the sputum output in rats (P<0.05, P<0.01). SBZKG can reduce the mortality rate of mice infected with bacteria and viruses. CONCLUSION: SBZKG has certain anti-inflammatory, antitussive, expectorant, antibacterial and antiviral effects, and has certain therapeutic effects on acute tracheobronchitis.
