Efficacy and safety of interventional therapy combined with drug injection under bronchoscope in the treatment of central non-small cell lung cancer
10.12092/j.issn.1009-2501.2024.01.008
- Author:
Ling XU
1
;
Hua WANG
1
;
Ling XU
2
;
Wei YE
2
;
Liping LV
2
;
Hua WANG
3
;
Ling XU
4
Author Information
1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University
2. Department of Interventional Pulmonology, Anhui Provincial Chest Hospital
3. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University
4. The 5th Clinical College of Anhui Medical University
- Publication Type:Journal Article
- Keywords:
drug injection;
interventional therapy;
non-small cell lung cancer;
tracheoscope
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(1):76-81
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the efficacy and safety of interventional therapy combined with tumor drug injection under bronchoscope for central non-small cell lung cancer (NSCLC). METHODS: Sixty-four patients who met the test admission criteria were randomly assigned to the experimental group and the control group according to the ratio of 1:1, and were given bronchoscopic interventional therapy combined with local drug injection of recombinant human endostatin combined with platinum-containing dual-drug chemotherapy and platinum-containing dual-drug alone, respectively. The curative efficiency and safety of the two groups were compared. RESULTS: Compared with the control group, the KPS score, dyspnea grading were significantly improved (P<0.05). The effective rate of the test group was 78.12%, which was higher than 37.5% in the control group, the difference between the two groups was significant (P<0.05). Moreover, there was also a significant difference in the 1-year survival rate between the experimental group and the control group (P<0.05). CONCLUSION: The treatment of central NSCLC by interventional therapy combined with tumor drug injection through fiberoptic bronchoscope has obvious clinical efficacy, which can effectively alleviate the clinical symptoms and improve the quality of life of patients. There is no significant difference in adverse reactions between the two groups, and is worthy of popularization and application.
