The antichlamydial activity of 1, 2-disubstituted pyrrole derivatives in vitro

Author: Shun-Xin XU ¹ ; Wen-Xia XIE ¹ ; Min NI ¹ ; Zi-Yi LIU ¹ ; Xiao-Feng BAO ¹ ; Ling-Yan LIU ²
Author Information

1. School of Pharmacy, Nantong University
2. The State Key Laboratory of Elemento-Organic Chemsitry, Nankai University
Publication Type:Journal Article
Keywords: 1,2-disubstituted pyrroles; antichlamydial; Chlamydia; in vitro; infection period; life cycle; proliferation period
From: Chinese Pharmacological Bulletin 2021;37(7):929-934
CountryChina
Language:Chinese
Abstract: Aim To evaluate the antichlamydial activity of our previously synthesized sixteen 1, 2-disubstituted pyrroles in vitro, providing candidate for the development of novel agents against Chlamydia. Methods Firstly, the inhibitory effect of compounds on the generation of infectious progeny EBs at different concentrations was analyzed for Chlamydia trachomatis L2 (Ct L2), C. muridarum (Nigg II strain, known as MoPn) and C. pneumonia (Cpn AR39). The IC