Research progress of breast cancer driver genes and precision therapy

Author: Yuan WANG ¹ ; Fang-Ming XU ¹ ; Jun-De XU ¹ ; Ye SUN ¹ ; Wen-Xing CHEN ¹ ; Yin LU ¹ ; Yuan-Yuan WU ¹ ; Wen-Xing CHEN ² ; Yin LU ²
Author Information

1. JiangsuKey Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine
2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine
Publication Type:Journal Article
Keywords: breast cancer; driver genes; driver mutations; heterogeneity; precision medicine; targeted therapy
From: Chinese Pharmacological Bulletin 2021;37(7):889-892
CountryChina
Language:Chinese
Abstract: A large number of genetic mutations occur in the development of tumors, but only driver mutations determine the evolutionary direction of tumors. A variety of algorithmic tools and stationary analysis processes are available to search for driver genes with driver mutations. AS driver genes are different in different times and spaces, they are not the same in different stages of the development of breast cancer, leading to the different sensitivity of breast cancer patients to targeted therapy, which has become a major challenge for targeted therapy of breast cancer. This article reviews the progress and challenges of precision therapy for breast cancer from the perspective of driver genes.