Effects of sinapine thiocyanate on cutaneous squamous cell carcinoma and its related mechanism

Author: Yu-Shen SU ¹ ; Dong-Yun RONG ¹ ; Ye WANG ¹ ; Dan LI ¹ ; Xiang-Shi YUAN ¹ ; Shan-Shan TANG ¹ ; Yu CAO ¹ ; Yu-Shen SU ² ; Dong-Yun RONG ² ; Ye WANG ² ; Dan LI ² ; Xiang-Shi YUAN ² ; Shan-Shan TANG ² ; Yu CAO ² ; Zhi-Rui ZENG ³ ; Zhi-Rui ZENG ⁴
Author Information

1. School of Clinical Medical Institution
2. Dept of Dermatology, Affiliated Hospital of Guizhou Medical University
3. Dept of Physiology, School of Bask Medical Science, Guizhou Medkal University
4. Key Lab of Pathogenesis and Drug Research of Common Chronk Diseases in Guizhou Province
Publication Type:Journal Article
Keywords: AKT/β-catenin pathway; cutaneous squamous cell carcinoma; invasion; migration; proliferation; sinapine thiocyanate
From: Chinese Pharmacological Bulletin 2021;37(6):852-860
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of sinapine thiocyanate (ST) on the malignant biological behavior of cutaneous squamous cell carcinoma A431 and Colo-16 cells, and its mechanism. Methods The fibroblast cells were treated with 20 μmol · L