Mechanism of Duhuo Jisheng decoction in treatment of knee osteoarthritis based on network pharmacology
10.3969/j.issn.1001-1978.2021.05.020
- Author:
Qi-Yun SHI
1
;
Xu-Yi TAN
1
;
Min LU
1
;
Wu-Yin LI
2
Author Information
1. Graduate School, Hunan University of Chinese Traditional Medicine
2. Drug Lab of Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province
- Publication Type:Journal Article
- Keywords:
Duhuo Jisheng decoction;
knee osteoarthritis;
mechanism;
network pharmacology;
signaling pathway;
target
- From:
Chinese Pharmacological Bulletin
2021;37(5):704-709
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the mechanism of Duhuo Jisheng decoction in the treatment of knee osteoarthritis (KOA) by network pharmacology. Methods The active components of Duhuo Jisheng decoction were screened on traditional Chinese medicine systems pharmacology (TCMSP) platform according to research criteria, and the targets of KOA were predicted in GeneCards database. The "TCM-component-target-disease" network was constructed by Cytoscape software. The Venn diagram was built to extract the target of Duhuo Jisheng decoction in the treatment of KOA. The PPI network of Duhuo Jisheng decoction in the treatment of KOA was constructed, and the network feature analysis was made by Network Analyzer. The gene oesthetics (GO) function annotation and Kyoto Encyclopedin of Genes and Genomes (KEGG) signaling pathway enrichment analysis were performed. Results Totally 154 components and 130 potential targets in Duhuo Jisheng decoction and 1878 targets relating to KOA were excavated, and 63 common targets of Duhuo Jisheng decoction-ROA were obtained. The common targets were mainly enriched in 68 biological processes and 117 signaling pathways. Conclusions Duhuo Jisheng decoction may regulate targets, such as IL6, VEGFA, ALB, EGFR, CASP3, MAPK8, MYC, and adjust AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway and apoptosis, so as to inhibit the inflammatory response and adjust apoptosis to treat KOA.
