Cyclovirobuxine D ameliorates aldosterone-induced primary neonatal rat cardiac myocyte injury via Ca

Author: Guang-Qiong ZHANG ¹ ; Sheng-Quan WANG ¹ ; Ling-Yun FU ¹ ; Yi-Ni XU ¹ ; Hong LUO ¹ ; Ling TAO ¹ ; Xiang-Chun SHEN ¹ ; Ling LI ¹ ; Guang-Qiong ZHANG ² ; Sheng-Quan WANG ² ; Ling-Yun FU ² ; Yi-Ni XU ² ; Hong LUO ² ; Ling TAO ² ; Xiang-Chun SHEN ² ; Ling LI ²
Author Information

1. The Slate Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University
2. The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University
Publication Type:Journal Article
Keywords: aldosterone; apoptosis; calcium ion; CaMK II; cyclovirobuxine D; myocardial cell injury
From: Chinese Pharmacological Bulletin 2021;37(4):564-570
CountryChina
Language:Chinese
Abstract: Aim To investigate the protective effect of cyclovirobuxine D(CVB-D) on aldosterone (ALD)-induced primary neonatal rat cardiac myocytes (PNRC-Ms) injury and the possible mechanism. Methods PNRCMs were extracted by trypsin, and the PNRCMs injury model was established by ALD (10 μmol · L