Research progress on effects of high altitude hypoxia environment on antiepileptic drugs
- Author:
Lin HU
1
;
Long-Ji HUANG
1
;
Ning-Ning QIN
1
;
Yi-Ke SHEN
1
;
An-Peng ZHAO
1
;
Wen-Bing LI
1
;
Rong WANG
1
;
Lin HU
2
;
Long-Ji HUANG
2
;
Ning-Ning QIN
2
;
Yi-Ke SHEN
2
;
Rong WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: altitude hypoxia; antiepileptic drugs; dnjg concentration; dnjg metabolism; rational use; therapeutic drug monitoring
- From: Chinese Pharmacological Bulletin 2022;38(2):181-184
- CountryChina
- Language:Chinese
- Abstract: Hie high altitude hypoxic environment affects the pharmacokinetic process of rlnjgs by changing the body's gastrointestinal emptying rate, organ blood flow, drug plasma protein binding rate, dnjg metabolizing enzymes and transporter expression.Epilepsy is a brain disease that requires long-term medication.Most anti-epileptic drugs have a low therapeutic index and a narrow range of effective blood drug concentrations.'Ilierapeu- tic dnjg monitoring (TDM) is commonly used clinically to find the best individualized medication method for antiepileptic dnjgs.rI1iis article summarizes the commonly used anti-epileptic dnjgs and their treatment windows in clinical practice, and analyzes the influence of the pharmacokinetics of anti-epileptic dnjgs in the high altitude hypoxic environment, so as to provide reference for the clinical use of anti-epileptic drugs at high altitude.
