Baicalin enhances middle cerebral artery smooth muscle cells BK channel-mediated outward currents in SD rats
10.3969/j.issn.1001-1978.2022.01.010
- Author:
Sheng WANG
1
;
Lei-Lei JIANG
1
;
Wen WEI
1
;
Sheng WANG
2
;
Chuan-Lin ZHANG
2
;
Jia-Ning WANG
3
;
Chuan-Lin ZHANG
3
Author Information
1. Shihezi University Medical College, First Affiliated Hospital, Pharmacy Dept
2. Electrophysiological Laboratory., Laboratory of Xinjiang Endemic and Ethnic Diseases
3. Hubei University of Medicine, Renmin Hospital, Heart Function Dept
- Publication Type:Journal Article
- Keywords:
baicalin;
BK channel;
ibTX;
middle cerebral artery;
outward current;
patch clamp technique
- From:
Chinese Pharmacological Bulletin
2022;38(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effeet of baicalin on middle cerebral arterv in SD rats.Methods The j changes of middle cerebral artery diameter were observed using a pressure myograph system.The whole- cell and inside-out patch-clamp recording were used to detected the electrophysiological features of single vascular smooth muscle cells.Results Baicalin dilated the middle cerebral artery segment of SD rats in a con- centration-dependent manner.IbTX blocked baicalin - mediated relaxation.Baicalin enhanced the outward current of middle cerebral artery smooth muscle cells in a concentration-dependent manner.IbTX blocked ba- icalin-mediated outward current.Baicalin increased BK channel open probabilities.Conclusions Baicalin enhances the outward current mediated by BK channel and relaxes the middle cerebral arterv in SD rats.
