Research progress of organophosphorus pesticides / organophosphorus nerve agents' protein adducts and formation mechanism

Author: Jin WANG ¹ ; Feng-Juan SUN ¹ ; Hong -Mei WANG ¹ ; Run-Li GAO ¹ ; Fei WANG ²
Author Information

1. State Key Laboratory of Nbc Protection for Civilian
2. Equipment Project Management Center, Army Equipment Dept
Publication Type:Journal Article
Keywords: endogenous scavengers; formation mechanism; low-dose toxicity related proteins; organophosphorus nerve agents; organophosphorus pesticides; protein adducts
From: Chinese Pharmacological Bulletin 2022;38(4):481-487
CountryChina
Language:Chinese
Abstract: Organophosphorus pesticides ( OPP) and organophosphorus nerve agents ( OPNAs) are both toxic organophosphorus compounds, which mainly exert toxic effects through irreversible inhibition of acetylcholinesterase ( AChE).This paper takes protein adducts as the research objective, studying the covalent adducts formed by OPP/OPNAs and different target proteins:endogenous scavengers ( butyrylcholinesterase, albumin, transfer-rin) and low-dose toxicity related proteins ( Cytoskeleton pro- tein, neuropathic target esterase, ubiquitin ) .The formation mechanism of protein adducts and the structural characteristics of active sites are reviewed for providing new ideas to confirm the exposure, trace, and accurate treatment and reasonable prevention of OP poisons in the future.