IL-6 exacerbates potential arrhythmia of Chan Su intravenous injection
- Author:
Qian-Wen GAO
1
;
Yu-Jie XIAO
1
;
Yu-Wei WANG
1
;
Xiao-Jia ZHU
1
;
Long CHEN
1
;
Fu-Ming LIU
2
;
Ke-Su CHEN
3
;
Rong-Rong WANG
4
;
Long CHEN
4
Author Information
- Publication Type:Journal Article
- Keywords: action potential; arrhythmia; Ca2+ channel; ChanSu intravenous injection; IL-6; Na+ channel
- From: Chinese Pharmacological Bulletin 2022;38(5):712-718
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the arrhythmic risk of Chan Su intravenous injection(CS)and its underlying mechanismin in the absent or presence of IL-6.Methods The recording techniques of guinea pig in vivo ECG, the action potential, L-type Ca2+ and Na+ currents from left ventricular myocytes were used to analyze heart rate(HR), P-R, QRS and QTc intervals and the underlying mechanism.Results① CS at one time CRD(clinically relevant dose)insignificantly changed the guinea pig in vivo ECG.However, the IL-6(18.4 μg·kg-1)only and the combinational use of IL-6(18.4 μg·kg-1)plus CS(one time CRD)remarkably prolonged the P-R and QTc intervals.② The CS at one time CRC(clinically relevant concentration)had no significant change in the action potential duration at 90% repolarization level(APD90).The IL-6(20 μg·L-1)only and the combination of CS at one time CRC plus IL-6(20 μg·L-1)significantly prolonged APD90.③ Moreover, the IL-6(20 μg·L-1)combined with CS at one time CRC significantly inhibited the L-type Ca2+ current. CS at one, five, ten time CRC, IL-6(20 μg·L-1)alone and IL-6(20 μg·L-1)combined with CS had no significant effects on Na+current.Conclusions CS intravenous injection has low risk of arrhythmia in the clinical settings.However, in presence of high titer of IL-6 characterized by inflammation, CS may induce the atrioventricular conduction block due to the blockade effect on Ca2+ current by both of CS and IL-6.
