Advances in signaling pathway of 5-HT

Author: Hui-Li ZHU ¹ ; Feng-Hua FU ¹ ; Hui-Li ZHU ² ; Pei-Lan ZHOU ² ; Rui-Bin SU ²
Author Information

1. School of Pharmacy, Yantai University
2. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Publication Type:Journal Article
Keywords: 5-HT; G protein; G protein-coupled receptor; psychedelics; signal bias; signal transduction; β-arrestin 2
From: Chinese Pharmacological Bulletin 2022;38(11):1607-1612
CountryChina
Language:Chinese
Abstract: Classic serotonergic hallucinogens(also known as psychedelics)are powerful psychoactive substances that can induce profound alterations of human consciousness,emotion,and cognition. It is generally believed that the main target of psychedelics for their hallucinogenic effect is 5-hydroxytryptamine 2A receptor(5-HT