Research progress on mechanisms of neuroinflammation induced by methamphetamine and HIV-1 Tat protein

Author: Yi TAN ¹ ; Gen-Meng YANG ¹ ; Shu-Wei ZHANG ¹ ; Hui-Jie ZHANG ¹ ; Hao-Wei WANG ¹ ; Lin MIAO ¹ ; Yi LI ¹ ; Zhen LI ¹ ; Xiao-Feng ZENG ¹ ; Juan LI ²
Author Information

1. School of Forensic Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University
2. School of Basic Medicine, Kunming Medical University
Publication Type:Journal Article
Keywords: autophagy; cytokines; HIV-1 Tat protein; methamphetamine; neuroglial cells; neuroinflammation; NLRP3 inflammasome; oxidative stress; receptor
From: Chinese Pharmacological Bulletin 2023;39(8):1417-1421
CountryChina
Language:Chinese
Abstract: Methamphetamine abuse and HIV infection are extremely serious public health and social problems facing the world today. Methamphetamine and HIV-1 Tat protein can induce neurotoxicity in an individual and synergistic way, and neuroinflammation is one of the most important mechanisms for ca-using neurotoxicity. Neuroinflammation can be mediated by glial cells, cytokines, NLRP3 inflammasomes, etc. This paper reviews the research progress of neuroinflammation induced by methamphetamine and HIV-1 Tat protein in recent years, with the aim of providing reference and basis for further exploration of the mechanisms of neuroinflammation caused by them and effective drug intervention targets in the future.