Effect of total flavonoids of Rosa rugosa on PI3K/AKT pathway and endoplasmic reticulum stress apoptosis in rats with cerebral ischemia-reperfusion injury
- Author:
Jing-Rong ZHANG
1
;
Xiu-Shi YU
1
;
Rui-Juan GAO
1
;
Liang-Jing-Yuan KONG
1
;
Pan-Xi SUN
1
;
Chong-Yang ZHANG
1
;
Li-Li WEI
1
;
Jun-Qiang SI
1
;
Li LI
2
Author Information
- Publication Type:Journal Article
- Keywords: apoptosis; cerebral ischemia-reperfusion injury; endoplasmic reticulum stress; PI3K/AKT; rats; total flavonoids from Rosa rugosa
- From: Chinese Pharmacological Bulletin 2023;39(5):896-902
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effects of total flavonoids from Rosa rugosa (TFR) on cerebral ischemia reperfusion injury (CIRI) in rats, and to investigate whether TFR inhibited neuronal apoptosis by regulating phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway and endoplasmic reticulum stress (ERS) pathways. Methods SD rats were randomly divided into sham operation group, model group, low-dose group (50 mg · kg
