Advance in Traditional Chinese Medicine for Alzheimer's disease by regulating microglia

Author: Yu-Fan PAN ¹ ; Yu-Fan PAN ² ; Qi-Qi XIN ² ; Rong YUAN ² ; Yu MIAO ² ; Wei-Hong CONG ²
Author Information

1. Graduate School, Tianjin University of Traditional Chinese Medicine
2. National Clinical Research Center for Chinese Medicine Cardiology, Lab of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences
Publication Type:Journal Article
Keywords: Alzheimer's disease(AD); mechanism of action; microglia; neuro-inflammation; Traditional Chinese Medicine; β-amyloid peptide(Aβ)accumulation
From: Chinese Pharmacological Bulletin 2023;39(2):207-211
CountryChina
Language:Chinese
Abstract: Microglia, the main immune macrophages in the central nervous system, can be highly involved in the occurrence and development of Alzheimer's disease(AD)through microglia polarization and receptor protein expression. Traditional Chinese Medicine has been demonstrated to have regulatory effects on MG. Many active components in Traditional Chinese herbs play important roles in decreasing β-amyloid peptide(Aβ)accumulation, inhibiting neuro-inflammation and regulating microglia polarization etc. In this study the role of microglia in the pathogenesis of AD and the mechanism by which Traditional Chinese Medicine regulating microglia are reviewed to provide a reference for the treatment of AD.