Research progress on experimental animal models of hyperuricemia

Author: Yi-Song YUE ¹ ; Xue-Mei QIN ¹ ; Yi-Song YUE ² ; Wen ZHANG ² ; Yi-Fei XIE ² ; Guan-Hua DU ²
Author Information

1. Modern Research Center for Traditional Chinese Medicine, Shanxi University
2. Beijing Key Lab of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Publication Type:Journal Article
Keywords: animal model; gout; hyperuricemia; potassium oxazine; purine; uric acid
From: Chinese Pharmacological Bulletin 2023;39(2):201-206
CountryChina
Language:Chinese
Abstract: Hyperuricemia is a chronic metabolic disease caused by purine metabolism disorder or uric acid excretion disorder. The experimental animal model of hyperuricemia is the basis for studying the pathological mechanism and drug treatment of hyperuricemia. This paper reviews the experimental animal models of hyperuricemia commonly used in drug research, and introduces the modeling principle, preparation methods, species selection and related detection techniques of the models, so as to provide reference for the application of such models in research.