Effect of phillygenin on inflammatory response of A549 cells induced by lipopolysaccharide and normal human plasma

Author: Jing GUO ¹ ; Xiang JIN ¹ ; Huan-Huan XUE ¹ ; Li-Wei ZHANG ¹ ; Jing GUO ² ; Qi-Yun ZHANG ² ; Qing-Yu LU ² ; Li GUO ² ; Qian-Yun SUN ² ; Jing GUO ³ ; Qi-Yun ZHANG ⁴ ; Qing-Yu LU ⁴ ; Li GUO ⁴ ; Qian-Yun SUN ⁴
Author Information

1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Mordern Research Center for Traditional Chinese Medicine, Shanxi University
2. Key Laboratory of Chemistry for Natural Products, Guizhou Province and Chinese Academy of Science
3. KweiChow Moutai Hospital
4. State Key Laboratory of Function and Applications of Medicinal Plants, Guizhou Medical University
Publication Type:Journal Article
Keywords: A549 cells; acute lung injury; CD14; lipopolysacchride; Nf-κB/MAPK signaling pathway; normal human plasma; phillygenin
From: Chinese Pharmacological Bulletin 2023;39(3):503-511
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of phillygenin ( PHI) on lipopolysacchride ( LPS) and normal human plasma ( NHP) induced inflammatory injury on alveolar type II epithelial A549 cells and the related mechanism. Methods A549 cells were exposured to 1 mg • L