Research progress of improving demyelination in treatment of spinal cord injury

Jing FENG; Juan-Fang WEI; Yan-Ru CUI; Jing FENG; Juan-Fang WEI; Yan-Ru CUI; An-Ren ZHANG; An-Ren ZHANG

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Research progress of improving demyelination in treatment of spinal cord injury

Author: Jing FENG ¹ ; Juan-Fang WEI ¹ ; Yan-Ru CUI ¹ ; Jing FENG ² ; Juan-Fang WEI ² ; Yan-Ru CUI ² ; An-Ren ZHANG ² ; An-Ren ZHANG ³
Author Information

1. School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine
2. Dept of Rehabilitation Medicine, General Hospital of the Western Theater of the People's Liberation Army
3. Dept of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine
Publication Type:Journal Article
Keywords: demyelination; differentiation; myelin regeneration; oligodendrocytes; Schwann cells; spinal cord injury
From: Chinese Pharmacological Bulletin 2023;39(4):617-621
CountryChina
Language:Chinese
Abstract: Axonal demyelination is an important factor causing neurological dysfunction after spinal cord injury. Retaining the integrity of myelin sheath and promoting remyelination play an important role in the functional recovery of spinal cord injury. The bottleneck of the failure of remyelination is the inability of myelin-forming cells (oligodendrocytes and Schwann cells) to differentiate and mature. In recent years related research on spinal cord injury demyelination has found that cell transplantation, neuregulin-1 and hydrogel can effectively enhance remyelination, and identified aquaporin-4 (aquaporin-4, AQP4), metal-loproteinase (Matrix metailoproteinase, MMP) may be a potential therapeutic target to promote myelin recovery after spinal cord injury. This review discusses the research progress of enhancing remyelination after spinal cord injury, providing ideas for the further development of new methods for the treatment of spinal cord injury.