Regulation of platelet function by cantharidin via PI3K/Akt/PKC pathway

Author: Fang GUO ¹ ; Xiao-Yun TIAN ¹ ; Xiu-Qin XIONG ¹ ; Zhao-Wei YUAN ¹ ; Li ZHANG ¹ ; Yu-Jing YUAN ¹ ; Tao LIU ¹ ; Gang LIU ¹ ; Gang LIU ² ; Gang LIU ³
Author Information

1. Dept of Pharmacology, School of Basic Medical Sciences, Guizhou Medical University
2. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R and D
3. Guizhou Provincial Key Laboratory of Patho Genesis and Drug Research on Common Chronic Diseases
Publication Type:Journal Article
Keywords: antiplatelet drugs; cantharidin; clot retraction; PI3 K/Akt; PKC signaling pathway; platelet aggregation
From: Chinese Pharmacological Bulletin 2023;39(7):1248-1255
CountryChina
Language:Chinese
Abstract: To investigate the effect of cantharidin ( CTD) on platelet function and the mechanism of anti-platelet aggregation. Methods Washed platelets were collected from the venous blood of healthy volunteers. The effect of CTD on platelet aggregation and release was determined by aggregometer. The CTD concentration was 2.5 ,5 ,10 μmol • L