Eplerenone protects contralateral kidney tissue from obstruction in pregnant rats with chronic kidney disease
- Author:
Chang XU
1
;
Wen-Ping ZHOU
1
;
Jie-Qi NIU
1
;
Hong-Shuang WANG
1
;
Meng-Juan ZHANG
1
;
Jia-Zhi LIU
1
;
Chang XU
2
;
Qing-You XU
2
;
Wen-Ping ZHOU
2
;
Jie-Qi NIU
2
;
Yun-Zhao XIONG
2
;
Yan ZHONG
2
;
Zheng WANG
2
;
Qing-You XU
3
;
Yun-Zhao XIONG
3
;
Yan ZHONG
3
;
Xiang-Ting WANG
3
;
Zheng WANG
3
;
Hong-Shuang WANG
4
;
Meng-Juan ZHANG
4
;
Jia-Zhi LIU
4
Author Information
- Publication Type:Journal Article
- Keywords: chronic kidney disease; eplerenone; lymphangiogenesis; obstruction of contralateral kidney; pregnancy; renal fibrosis; SGK-1/N F - Κ B signaling pathway
- From: Chinese Pharmacological Bulletin 2023;39(8):1534-1540
- CountryChina
- Language:Chinese
- Abstract: Aim To study the protective effect of eplerenone on the contralateral kidney in pregnant rats with chronic kidney disease (CKD) and its mechanism. Methods Female Wistar rats were randomly divided into sham-operation group, sham-operation pregnancy group, model group and eplerenone group. The rats in the model group and eplenone group had ligation unilateral ureter, and the rats in the eplenone group were treated with 100 mg • kg
