Dapagliflozin regulates myocardial SK2 protein expression in diabetic rats

Author: Min WU ¹ ; Jiang-Yan ZHAO ¹ ; Min WU ² ; Jiang-Yan ZHAO ² ; Min LEI ² ; Qing-Jie CHEN ² ; Xi-Ying GUO ²
Author Information

1. School of Pharmacy, Dept of Medical, Hubei University of Science and Technology
2. Hubei Provincial Key Laboratory of Diabetic Cardiovascular Diseases, Hubei University of Science and Technology
Publication Type:Journal Article
Keywords: cardiomyopathy; dapagliflozin; diabetes; NOX4/p38MAPK signaling pathway; oxidative stress; small conductance calcium-activated potassium channel
From: Chinese Pharmacological Bulletin 2023;39(8):1478-1484
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of dapagliflozin on the small conductance calcium-activated potassium channel 2 (SK2 channel) protein in the myocardium of diabetic rats and its possible mechanism of action. Methods In vivo: type 2 diabetes model was established by high-glucose and high-fat diet combined with intraperitoneal injection of low-dose streptozotocin (35 mg