Research progress on potential therapeutic targets of chronic cough

Author: Jia LIU ¹ ; Yong-Ping ZHANG ¹ ; Xiao-Bo SUN ¹ ; Jia LIU ² ; Yun LUO ² ; Yun-Feng PAN ² ; Xi DONG ² ; Xiao-Bo SUN ²
Author Information

1. School of Pharmacy, Guizhou University of Traditional Chinese Medicine
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences
Publication Type:Journal Article
Keywords: central nervous target; chronic cough; neurokinin-1 receptors; P2X3 receptors; peripheral nervous target; voltage-gated sodium channels
From: Chinese Pharmacological Bulletin 2023;39(8):1426-1429
CountryChina
Language:Chinese
Abstract: Chronic cough is caused by low levels of heat, mechanical or chemical exposure, which is characterized by the disorders of channels and receptors in neuroregulation such as the peripheral and central nerves. Potential regulatory targets of peripheral nerves include P2X3 receptors and transient receptor potential channels, while potential regulatory targets of central nerves include voltage-gated sodium channels, neurokinin-1 receptors, α-7acetylcholine receptors and gamma aminobutyric acid receptors. This paper focuses on the principle and clinical research evidence of several ongoing targeted therapy strategies, in order to provide new ideas for the development of drugs for the treatment of chronic cough.