Radiosensitizing effect of PARP-1 inhibitor Olaparib on MCF-7 breast cancer and hypoxic imaging

Author: A-Lei XU ¹ ; Yang-Yang XUE ¹ ; Wei-Tao TAO ¹ ; Si-Qi WANG ¹ ; Hui-Qin XU ¹ ; Juan JIN ²
Author Information

1. Dept of Nuclear Medicine, The First Affiliated Hospital of Anhui Medical University
2. School of Basic Medical Sciences, Anhui Medical University
Publication Type:Journal Article
Keywords: F-FETNIM; MCF-7; PARP inhibitor; Radiosensitivity; Radiotherapy; Tumor hypoxia
From: Chinese Pharmacological Bulletin 2023;39(9):1668-1674
CountryChina
Language:Chinese
Abstract: Aim To investigate the radiosensitizing effect of the PARP inhibitor Olaparib on MCF-7 breast cancer model and to monitor the radiosensitizing effect of Olaparib by F-Fluoroerythronitroimidazole (F-FETNIM) PET/CT. Methods MCF-7 breast cancer model was established and divided into control group, Olaparib group, irradiation group and Olaparib + irradiation group according to random number table method; tumor volume was measured to calculate tumor inhibition rate and survival time of tumor-bearing mice was counted.