Effect of Liuwei Dihuang decoction on β-catenin and EMT in kidney tissue of UUO rats
- Author:
Hui WANG
1
;
Hai-Ying ZHANG
1
;
Hai-Bo GAO
1
;
Jin-Jing GUO
1
;
Qun TANG
1
;
Gang PEI
2
Author Information
- Publication Type:Journal Article
- Keywords: EMT; histopathology; Liuwei Dihuang decoction; renal fibrosis; unilateral ureteral obstruction; β-catenin
- From: Chinese Pharmacological Bulletin 2023;39(12):2385-2389
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the effect of Liuwei Dihuang decoction ( LWDHD) on the expression of β-catenin, E-cadherin,α-SMA, the pathological changes of renal tissue, and the changes of an epithelial-mesen-chymal transformation ( EMT) in renal tissue of rats with unilateral ureteral obstruction ( UUO ) . Methods Forty-eight SPF grade SD rats were randomly divided into sham group ( Sham), model group ( UUO), Liuwei Dihuang decoction low, medium, and high groups ( LWDHD 3. 375, 6. 75, 13. 5 g · kg
