Research progress on phenotype and function of microglia
- Author:
Xiao-Tong WEI
1
;
Qi-Chun ZHANG
1
;
Rui GUO
2
Author Information
- Publication Type:Journal Article
- Keywords: disease-associated microglia; function; microglia; phenotype; triggering receptor expressed on myeloid cells 2; white matter-associated microglia
- From: Chinese Pharmacological Bulletin 2024;40(3):410-415
- CountryChina
- Language:Chinese
- Abstract: Microglia are the central nervous system's resident myeloid-derived immune cells, which play a major role in the innate and acquired immunological responses of brain. In the maintenance of brain tissue function under both healthy and pathological conditions, microglia take a protective or damaging role, depending on cell phenotypes and functions. The traditional microglia classification of pro- or anti-inflammatory phenotypes refers to the profile of macrophages, hence the term “brain macrophages:has been drawn. More microglia phenotypes are being discovered as new technologies and research methods are developed, and the newly discovered microglia phenotypes are often disease-, brain region-, and function-specific, providing an important foundation for studying the pathological processes underlying the development of specific diseases and developing appropriate interventions. Here, we provide a retrospective review of recent advances in the study of phenotype and function of microglia, and analyze the microglial cell lineage composition and its heterogeneous function.
