Mechanism of EGFR inhibitor AG1478 combined with oxaliplatin in inhibiting PI3K/AKT pathway and promoting autophagy in HI 975 cells

Author: Jin-Qing HUANG ¹ ; Yang LI ¹ ; Dong-Xue WEI ¹ ; Shan JIANG ¹ ; Shao-Feng JIANG ¹
Author Information

1. College of Basic Medical Sciences, Guilin Medical University, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation
Publication Type:Journal Article
Keywords: AG1478; autophagy; non-small cell lung cancer; oxaliplatin; PI3K/AKT signaling pathway; ROS
From: Chinese Pharmacological Bulletin 2024;40(2):242-278
CountryChina
Language:Chinese
Abstract: Aim To explore the effect of oxaliplatin combined with epidermal growth factor receptor tyrosine kinase inhibitor AG1478 on autophagy in non-small cell lung cancer H1975 cells. Methods H1975 cells were cultured in vitro using gradient concentrations of AG1478 (0, 5, 10, 15, 20, 25, 30, 35, 40 jjimol • IT