Establishment and genotype identification of hepatic stellate cell-specific Grk2 gene knockout mouse model
- Author:
Yu-Han WANG
1
;
Ya-Ping XU
1
;
Nan LI
1
;
Ting-Ting CHEN
1
;
Ling LI
1
;
Ping-Ping GAO
1
;
Wei WEI
1
;
Wu-Yi SUN
1
;
Hua WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: breeding; cell specific knockout; Cre-loxP recombinase system; G protein-coupled receptor kinase 2; genotyping identification; hepatic stellate cell
- From: Chinese Pharmacological Bulletin 2024;40(1):189-194
- CountryChina
- Language:Chinese
- Abstract: Aim To establish a stable hepatic stellate cell ( HSC ) -specific G protein-coupled receptor kinase 2 ( GRK2 ) knockout mice and provide the important animal model for further studying the biological function of GRK2 in HSC. Methods The loxP-labeled Grk2 gene mouse (Grk2
