Effect of exogenous hydrogen sulfide on hypoxia/reoxygenation injury in glomerular mesangial cells and its mechanism

Author: Zhen-Ting LIN ¹ ; Hua TIAN ¹ ; Hong-Zhu LI ²
Author Information

1. Dept of Basic Medicine, Xiamen Medical College
2. Dept of Basic Education, School of Medicine, Xiamen University
Publication Type:Journal Article
Keywords: cell apoptosis; CSE/H; ERkl/2 pathway; glomerular mesangial cells; hydrogen sulfide; hypoxia/reoxygenation
From: Chinese Pharmacological Bulletin 2024;40(1):133-138
CountryChina
Language:Chinese
Abstract: Aim To explore the effect of exogenous hydrogen sulfide ( H2 S ) on hypoxia/reoxygenation ( H/R) injury in glomerular mesangial cells and elucidate its relevant mechanism. Methods H/R induced mouse mesangial cell line ( SV40MES13 ) to establish cell damage model. Cell viability was detected by cell proliferation kit ( CCK8 ), the content of H