Effect Xuefu Zhuyu decoction on endothelial-to-mesenchymal transition of pulmonary artery endothelial cells and its mechanism
- Author:
Zuo-Mei ZENG
1
;
Xin-Yue WANG
1
;
Lei-Yu TIAN
1
;
Li-Dan CUI
1
;
Jian GUO
1
;
Yu-Cai CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: endothelial-to-mesenchymal transition; pulmonary hypertension; pulmonary mi-crovascular endothelial cells; TGF-β1; TGF-β1/Smad signaling pathway; Xuefu Zhuyu decoction
- From: Chinese Pharmacological Bulletin 2024;40(1):155-161
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of Xuefu Zhuyu decoction on transforming growth factor-β1(TGF-β1 ) -induced endothelial-to-mesenchymal transition (EndMT) of pulmonary microvascular endothelial cells ( PMVEC), and further analyze the mechanism related to the TGF-β1/Smad signaling pathway. Method To construct an EndMT cell model, PMVEC was treated with TGF-β1 (5 μg · L
