Mechanism of ellagic acid improving cognitive dysfunction in APP/PS double transgenic mice based on PI3K/AKT/GSK-3β signaling pathway
- Author:
Li-Li ZHONG
1
;
Xin LU
1
;
Ying YU
1
;
Qin-Yan ZHAO
1
;
Jing ZHANG
1
;
Tong-Hui LIU
1
;
Xue-Yan NI
1
;
Li-Li ZHONG
2
;
Yan-Ling CHE
2
;
Dan WU
2
;
Hong LIU
3
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer's disease; APP/PS1 double transgenic mice; ellagic acid; glycogen synthase kinase-3 (GSK-3 β); phosphatidylinositol 3-kinase (PI3K); protein kinase B (AKT)
- From: Chinese Pharmacological Bulletin 2024;40(1):90-98
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of ellagic acid (EA) on cognitive function in APP/PS 1 double- transgenic mice, and to explore the regulatory mechanism of ellagic acid on the level of oxidative stress in the hippocampus of double-transgenic mice based on the phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase-3 (PI3K/AKT/GSK-3 β) signaling pathway. Methods Thirty-two SPF-grade 6-month-old APP/PS 1 double transgenic mice were randomly divided into four groups, namely, APP/PS 1 group, APP/PS1 + EA group, APP/PS1 + LY294002 group, APP/PS 1 + EA + LY294002 group, with eight mice in each group, and eight SPF-grade C57BL/6J wild type mice ( Wild type) were selected as the blank control group. The APP/PS 1 + EA group was given 50 mg · kg
