Effect of menthol on hypobaric hypoxia-induced pulmonary arterial hypertension in mice and its mechanism

Author: Wu-Shuai WANG ¹ ; Ying-Rong HE ¹ ; Xi YANG ¹ ; Qing-Hua DUAN ¹ ; Qiang WANG ¹ ; Wu-Shuai WANG ² ; Tao HU ² ; Ying-Rong HE ² ; Xi YANG ² ; Qing-Hua DUAN ² ; Xuan DU ² ; Qiang WANG ² ; Yao YANG ³ ; Xuan DU ⁴
Author Information

1. Dept of Cardiology, Clinical College of Medicine, Southwest Medical University
2. Dept of Cardiology, The General Hospital of Western Theater Command
3. Dept of Pharmacy, General Hospital of Western Theater Command
4. Chengdu Medical college
Publication Type:Journal Article
Keywords: hypobaric hypoxia-induced pulmonary arterial hypertension; Kruppel-like factor 4; menthol; pulmonary artery smooth muscle cells (PASMCs); pulmonary vascular remodeling; transient receptor potential melastatin 8 (TRPM8)
From: Chinese Pharmacological Bulletin 2024;40(1):62-69
CountryChina
Language:Chinese
Abstract: Aim To study the effect of menthol on hypobaric hypoxia-induced pulmonary arterial hypertension and explore the underlying mechanism in mice. Methods 10 to 12 weeks old wild type (WT) mice and TRPM8 gene knockout (TRPM8