Advances of pathogenesis and drug development in amyotrophic lateral sclerosis

Author: Yu-Jun ZHOU ¹ ; Qiu-Yu CHEN ¹ ; Zhuo SUN ¹ ; Jing-Shu TANG ¹ ; Jia-Qi LAN ¹ ; Lei WU ¹ ; Ying PENG ¹
Author Information

1. Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College
Publication Type:Journal Article
Keywords: amyotrophic lateral sclerosis; axon damage; glutamate-induced excitotoxicity; mitochondrial dysfunction; neuroinflammation; oxidative stress; protein aggregation; skeletal muscle deterioration
From: Chinese Pharmacological Bulletin 2024;40(2):201-207
CountryChina
Language:Chinese
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons. ALS patients develop progressive muscle atrophy, muscle weak and paralysis, finally died of respiratory failure. ALS is characterized by fast aggression and high mortality. What' s more, the disease is highly heterogeneous with unclear pathogenesis and lacks effective drugs for therapy. In this review, we summarize the main pathological mechanisms and the current drugs under development for ALS, which may provide a reference for the drug discovery in the future.