Study on extraction technology of Sophora flavescens-Phellodendron chinense drug pair
- VernacularTitle:苦参-黄柏药对的提取工艺研究
- Author:
Yongmei GUAN
1
;
Ying TAO
1
;
Chengyu ZOU
1
;
Zhenzhong ZANG
1
;
Lihua CHEN
1
;
Lili LIU
1
;
Limei CHEN
2
;
Weifeng ZHU
1
Author Information
1. Key Laboratory of Modern Preparation of TCM，Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China
2. Key Laboratory of Modern Preparation of TCM，Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China;Research Department，the Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
Sophora flavescens;
Phellodendron chinense;
drug pair;
Box-Behnken design;
response surface method
- From:
China Pharmacy
2024;35(7):793-800
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the extraction technology of Sophora flavescens-Phellodendron chinense drug pair and provide a reference for the development of new drugs for the treatment of anorectal diseases. METHODS Using the contents of total alkaloids of S. flavescens （matrine+oxymatrine）， berberine hydrochloride and total flavonoid， and extract yield as evaluation indicators， analytic hierarchy process-entropy weight method was used to calculate the weight coefficient of each indicator， and was combined with Box-Behnken design-response surface method to study the extraction technology of S. flavescens-P. chinense drug pair and verify it. RESULTS The optimal extraction technology of S. flavescens-P. chinense drug pair was immersed in 12-fold amount of 58% ethanol for 30 minutes and extracted twice， each time for 120 minutes. The relative error between the verification experimental results and the predicted value was 1.88%. CONCLUSIONS The obtained extraction technology is stable and feasible and can provide reference for the application of S. flavescens-P. chinense drug pair and development of new drugs.
