Progressive Changes of Colitis Into Colorectal Cancer Associated With Changes in Neutrophil Lymphocyte Ratio, Serum, Micrornas and Infiltrate Neutrophils
https://doi.org/10.47836/mjmhs.20.1.26
- Author:
Pang Jyh Chyang
1
;
Nur Farhana Elida
1
;
Chin Siok Fang
2
;
Rahim Md Noah
1
;
Hanan Kumar
1
Author Information
1. Institute of Medical Science Technology (MESTECH), Universiti Kuala Lumpur, 43000 Kajang Selangor, Malaysia
2. Universiti Kebangsaan Malaysia, Institut Perubatan Molekul (UMBI), Malaysia
- Publication Type:Journal Article
- Keywords:
Colitis, Colorectal cancer, Neutrophil, microRNAs
- From:Malaysian Journal of Medicine and Health Sciences
2024;20(No.1):200-204
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Understand the progression of colorectal cancer from the beginning until the advance stages is difficult
and challenging. However, this could be overcome with a good animal model. Methods: In this study, a modified approach had been used to develop colorectal cancer model. The model was developed and monitored from colitis formation until the late stage of colorectal cancer. The changes of neutrophil lymphocyte ratio (NLR), serum microRNAs
and infiltrate neutrophil in different stages of colorectal cancer were assessed in this study. Results: Results showed
that the progression of the disease is correlated with NLR as early as the formation of colitis (r=0.121, p<0.026).
Meanwhile, the size of the tumor at each stage is also associated with the NLR value (r=0.185, p<0.0012). In the
serum microRNAs study, it was found microRNAs expression in blood serum change in different stages of colorectal
cancer. In the early stage of colitis formation, miR223 (> 3 fold expression, p < 0.0025) were abundantly found in the
blood serum. Meanwhile in others stage mild (miRNA345 > 2.5 fold, p<0.0011), moderate (miRNA347 & miR512 >
3 fold, p<0.002) and severe (miR31 & miR145 > 2 fold, p<0.0001) microRNAs were also found expressed differently.
The quantities of infiltrate neutrophil were varied in different stages of the disease. Conclusion: This study provides
an insight into the immunity and molecular level of colorectal cancer and it allows a progressive monitoring on the
changes in the molecular, cellular and histological level.
- Full text:11.2024my1730.pdf
