Characteristics and impact factors of SARS-CoV-2 infection in adult patients with relapsed/refractory B-cell non-Hodgkin lymphoma receiving chimeric antigen receptor T-cell therapy.
10.3760/cma.j.issn.0253-2727.2023.10.006
- VernacularTitle:接受CAR-T细胞治疗的复发/难治性B细胞非霍奇金淋巴瘤患者新型冠状病毒感染特点及其影响因素
- Author:
Tong GE
1
;
Hui LIU
2
;
Zhen Hao WANG
1
;
Yang CAO
1
;
Yi Cheng ZHANG
1
;
Liang HUANG
1
;
Wen Bin QIAN
2
;
Xiao Xi ZHOU
1
Author Information
1. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2. Department of Hematology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- Keywords:
B-cell non-Hodgkin lymphoma;
COVID-19;
COVID-19 infection;
Chimeric antigen receptor T-cells
- MeSH:
Humans;
Adult;
Middle Aged;
Receptors, Chimeric Antigen;
Retrospective Studies;
COVID-19/therapy*;
SARS-CoV-2;
Lymphoma, B-Cell/therapy*;
Cell- and Tissue-Based Therapy
- From:
Chinese Journal of Hematology
2023;44(10):825-831
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical characteristics and treatment of COVID-19 infection in patients with relapsed/refractory B-cell non-Hodgkin lymphoma before and after receiving chimeric antigen receptor T-cell therapy, and study the influencing factors of severe COVID-19 infection in these patients. Methods: The data of 59 patients with relapsed/refractory B-cell non-Hodgkin lymphoma who received chimeric antigen receptor T-cell therapy at the Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology and Department of Hematology, the Second Affiliated Hospital, College of Medicine, Zhejiang University between December 2017 and February 2023, and who were infected with novel coronavirus between December 2022 and February 2023 were retrospectively studied. Patients were divided into light, medium, severe, and critical groups, and the differences between the groups were analyzed using the chi-square test. A univariate logistic regression model was used to evaluate the contribution of each variable and its relationship with severe infection. The chi-square and Fisher's exact tests were used to analyze the differences between the B-cell aplasia and B-cell recovery (BCR) groups. Results: Of the 59 pre- and post-infusion infections, 39 (66.1%) led to mild COVID-19, 9 (15.3%) resulted in moderate COVID-19, 10 (16.9%) resulted in severe COVID-19, and 1 (1.7%) led to critical COVID-19. Moroever, age greater than 55 years, having received autologous hematopoietic stem cell transplantation, progressive disease status, and B-cell aplasia at the time of diagnosis of COVID-19 infection are factors affecting severe infection. Patients with B-cell aplasia had a more severe infection with COVID-19 (P<0.001), a longer duration (P=0.015), a longer antiviral therapy course (P<0.001), and a higher hospitalization rate (P<0.001) than the BCR group. Conclusion: Active prevention and treatment of COVID-19 infection remains a crucial issue requiring urgent attention in managing patients with relapsed/refractory B-cell non-Hodgkin lymphoma treated with chimeric antigen receptor T-cell therapy.
