Research Progress on Active Ingredients of Chinese Medicine Based on AMPK Signaling Pathway to Improve Insulin Resistance in T2DM
10.13422/j.cnki.syfjx.20231204
- VernacularTitle:基于AMPK信号通路改善T2DM胰岛素抵抗中药有效成分研究进展
- Author:
Xiaomeng WANG
1
;
Peng YANG
1
;
Xiaochen LI
1
;
Lili WU
2
;
Lingling QIN
2
;
Tonghua LIU
2
Author Information
1. First Clinical College of Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. Key Laboratory of Chinese Medicine Nutrition and Preventive Medicine，Ministry of Education， Beijing University of Chinese Medicine，Beijing 100029，China
- Publication Type:Review
- Keywords:
adenosine monophosphate-activated protein kinase （AMPK） signaling pathway;
insulin resistance;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(7):247-255
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance （IR） is an important pathological and physiological mechanism of type 2 diabetes （T2DM）， and the treatment of IR has become the key to the prevention and treatment of T2DM. IR is a state of insensitivity or reduced sensitivity of insulin-stimulated tissue cells to glucose， resulting in cells that are unable to efficiently take up glucose in the bloodstream and thus causing hyperglycemia. Adenosine monophosphate-activated protein kinase （AMPK） is an energy-sensing enzyme that can regulate multiple metabolic pathways and maintain the stability of adenosine triphosphate （ATP） in the cell. In recent years， traditional Chinese medicine （TCM） has played an increasingly important role in the prevention and treatment of T2DM. The research on exploring the AMPK signaling pathway of TCM intervention in the progress of T2DM has gradually increased. Many pharmacological studies have shown that TCM has advantages such as safety and high efficiency in the prevention and treatment of T2DM. AMPK signaling pathway is one of the key pathways for the active ingredients of TCM and TCM extracts to improve IR. Active ingredients such as phenols， flavonoids， polysaccharides， alkaloids， and saponins， as well as other herbal extracts can improve IR by activating the AMPK signaling pathway cascade response， thereby improving IR by regulating glucolipid metabolism， inhibiting inflammatory response， anti-oxidative stress and maintaining mitochondrial homeostasis. Based on this， this paper reviews the pharmacological and experimental research results of TCM intervening the AMPK signaling pathway to improve IR in recent years， expecting to provide reference for further research， development and application of TCM in intervening IR and treating T2DM.
