Effect of Liuwei Dihuang Tang on ferroptosis pathway in retinal tissue of aging model rats
10.3980/j.issn.1672-5123.2024.3.02
- VernacularTitle:六味地黄汤对老化模型大鼠视网膜组织铁死亡通路的影响
- Author:
Qi ZHANG
1
;
Lei ZHAO
1
;
Tao ZUO
1
Author Information
1. Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
- Publication Type:Journal Article
- Keywords:
Liuwei Dihuang Tang;
aging;
retina;
ferritin;
ferroptosis
- From:
International Eye Science
2024;24(3):338-344
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of Liuwei Dihuang Tang on the expression levels of ferritin, recombinant solute carrier family 7 member 11(SLC7A11), glutathione(GSH), and glutathione peroxidase 4(GPX4)in retinal of aging model rats.METHODS: A total of 45 SD rats were randomly divided into a blank group, a model group, and a traditional Chinese medicine(TCM)group, with 15 rats in each group. The blank group was intraperitoneally injected with physiological saline, while the model group and TCM group were intraperitoneally injected with D-galactose [500 mg/(kg·d)]. At the same time, the TCM group was orally administered with Liuwei Dihuang Tang [6.75 g/(kg·d)], while the blank group and model group were orally administered with equal volume of physiological saline for 8 consecutive wk. The expression levels of ferritin, SLC7A11, GSH, and GPX4 in the retinal tissues of rats in each group were detected.RESULTS: The expression of ferritin in the retinal tissue of the model group was increased compared to the blank group(P<0.05), while the expression of GSH, SLC7A11, and GPX4 was reduced(P<0.05). The expression of GSH, SLC7A11, and GPX4 in the retina tissue of rats in the TCM group was higher than that in the model group(P<0.05).CONCLUSIONS: Liuwei Dihuang Tang may exert a delaying effect on retinal aging by regulating the ferroptosis pathway.
