Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults.
- Author:
Shao-Wei XUE
1
;
Tien-Wen LEE
1
;
Yong-Hu GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Trait anxiety; Fractional amplitude of low-frequency fluctuation (fALFF); Medial orbitofrontal cortex; Precuneus; Functional connectivity
- MeSH: Adult; Aged; Aged, 80 and over; Anxiety/physiopathology*; Brain/physiopathology*; Brain Mapping; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Phenotype; Prefrontal Cortex/physiopathology*; Surveys and Questionnaires; Young Adult
- From: Journal of Zhejiang University. Science. B 2018;19(8):643-653
- CountryChina
- Language:English
- Abstract: Medial orbitofrontal cortex (mOFC) abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging (R-fMRI) study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample (NKI-RS) to examine the relationship between the fractional amplitude of low-frequency fluctuation (fALFF) signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity (RSFC) between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.
