Correlation of anti-phosphatidylserine/prothrombin antibodies with unexplained recurrent miscarriages.
- Author:
Zhong Qiang YAO
1
;
Chang Hong LI
1
;
Xin Yi LI
1
;
Wei GUO
1
;
Jia Yu ZHAI
1
;
Rui LIU
1
;
Hui WEI
1
;
Rong MU
1
Author Information
1. Department of Rheumatology and Immunology, National Key Laboratory for Promoting Female Fertility, Peking University Third Hospital, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Anti-phosphatidylserine/prothrombin antibodies;
Correlation;
Recurrent miscarriages;
Sensitivity;
Specificity
- MeSH:
Pregnancy;
Female;
Humans;
Adolescent;
Young Adult;
Adult;
Prothrombin;
Retrospective Studies;
Phosphatidylserines;
Prospective Studies;
beta 2-Glycoprotein I;
Antibodies, Antiphospholipid;
Antiphospholipid Syndrome/diagnosis*;
Antibodies, Anticardiolipin;
Abortion, Habitual;
Immunoglobulin G;
Immunoglobulin M
- From:
Journal of Peking University(Health Sciences)
2023;55(6):1058-1061
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate whether anti-phosphatidylserine/prothrombin antibodies and its IgG or IgM subtypes were correlated with unexplained recurrent miscarriages.
METHODS:In our a single-center retrospective study, 283 patients with at least one unexplained miscarriage who visited the Third Hospital of Peking University between January 2021 and August 2023, aged between 18-40 years, and tested for anti-phosphatidylserine/prothrombin antibodies IgG or IgM subtypes, were included. The patients with either positive IgG or IgM anti-phosphatidylserine/prothrombin antibody were regarded as positive for anti-phosphatidylserine/prothrombin antibody. SPSS 26.0 software was used for statistical analysis. Chi-square test and Logistic regression analysis were used to study the correlation of anti-phosphatidylserine/prothrombin antibodies and its IgG or IgM subtypes with unexplained recurrent miscarriages. And the diagnostic sensitivity, specificity, the positive predictive value, the negative predictive value of anti-phosphatidylserine/prothrombin antibodies and its IgG or IgM subtypes in unexplained miscarriages was calculated with four-fold table.
RESULTS:Chi-square analysis showed that anti-phosphatidylserine/prothrombin antibodies and its IgM subtypes were correlated with recurrent miscarriages (both P < 0.05), while the IgG subtype was not correlated with recurrent miscarriages (P>0.05). After adjusting with anticardiolipin antibodies, anti-β2 glycoprotein antibodies, lupus anticoagulants, antinuclear antibodies, and age by Logistic regression analysis, anti-phosphatidylserine/prothrombin antibodies were correlated with unexplained recurrent miscarriages (OR=2.084, 95%CI 1.045-4.155, P < 0.05), and anti-phosphatidylserine/prothrombin antibody IgM subtypes were correlated with unexplained recurrent miscarriages (OR=2.368, 95%CI 1.187-4.722, P < 0.05).The sensitivity of anti-phosphatidylserine/prothrombin antibody in recurrent miscarriage was 65.43%, the specificity was 48.51%, the positive predictive value was 33.76%, and the negative predictive value was 77.78%. In the patients with recurrent miscarriages with negative classical antiphospholipid antibodies, the sensitivity of anti-phosphatidylserine/prothrombin antibody was 59.09%, the specificity was 63.23%, the positive predictive value was 40.63%, and the negative predictive value was 78.40%. The sensitivity of the anti-phosphatidylserine/prothrombin antibody IgM subtype for the diagnosis of recurrent miscarriage was 65.43%, the specificity was 50.99%, the positive predictive value was 34.87%, and the negative predictive value was 78.63%.
CONCLUSION:Anti-phosphatidylserine/prothrombin antibody and IgM subtype antibody are correlated with unexplained recurrent miscarriages in patients with at least one unexplained miscarriage. Whether positive anti-phosphatidylserine/prothrombin antibody or IgM subtype could predict future unexplained recurrent miscarriages warrants a prospective study.
