Clinical Analysis of Autologous Peripheral Blood Hematopoietic Stem Cells Mobilization and Collection in Lymphoma Patients.
10.19746/j.cnki.issn.1009-2137.2023.06.038
- Author:
Heng LIU
1
;
Rui XI
1
;
Hai BAI
1
;
Tao WU
2
Author Information
1. Department of Hematology, the 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, Gansu Province, China.
2. Department of Hematology, the 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, Gansu Province, China,E-mail：wutaozhen@yeah.net.
- Publication Type:Journal Article
- Keywords:
influencing factors;
CD34;
CTX;
VP16;
lymphoma;
peripheral blood hematopoietic stem cell collection
- MeSH:
Humans;
Antigens, CD34/metabolism*;
Neoplasm Recurrence, Local/drug therapy*;
Hematopoietic Stem Cell Mobilization;
Lymphoma/drug therapy*;
Granulocyte Colony-Stimulating Factor/pharmacology*;
Hematopoietic Stem Cells;
Hemoglobins;
Transplantation, Autologous;
Hematopoietic Stem Cell Transplantation
- From:
Journal of Experimental Hematology
2023;31(6):1845-1851
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the factors influencing collection of autologous peripheral blood hematopoietic stem cells in lymphoma patients.
METHODS:Clinical data of 74 patients who received autologous peripheral blood hematopoietic stem cells mobilization and collection in the 940th Hospital of Joint Logistic Support Force of PLA from April 2009 to April 2021 were collected. The effects of gender, age, disease type, stage, course of disease, chemotherapy cycle number, relapse, radiotherapy, disease status and blood routine indexes on the day of collection on peripheral blood hematopoietic stem cell collection were analyzed.
RESULTS:The success rate of collection was 95.9%(71/74), and the excellent rate of collection was 71.6%(53/74). There was a significantly statistical differentce in the number of CD34+ cells in grafts collected from patients with chemotherapy cycle ≤6 and >6 ［(9.1±5.2)×106/kg vs (6.4±3.7)×106/kg, P=0.031］. The number of CD34+ cells in the first collection was positively correlated with WBC count, hemoglobin, platelet count, neutrophil count, lymphocyte count, monocyte count and hematocrit value on the day of collection ( r value was 0.424,0.486,0.306,0.289,0.353,0.428,0.528, respectively). WBC count, hemoglobin, monocyte count and hematocrit value have higher predictive value for the first collection of CD34+ cells. The area under the receiver operating characteristic was 0.7061,0.7845,0.7319,0.7848, respectively.
CONCLUSION:Low dose CTX and VP16 chemotherapy combined with G-CSF can effectively mobilize autologous peripheral blood stem cells. The cycle number of chemotherapy relates to the collection of autologous peripheral blood stem cells. After mobilization, the success of the first collection can be better predicted by the blood routine indexes.
