Clinical Analysis of Infants with Acute Lymphoblastic Leukemia (18 cases).
10.19746/j.cnki.issn.1009-2137.2023.06.011
- Author:
Kai-Li LI
1
;
Hao XIONG
2
;
Hui LI
1
;
Zhuo WANG
1
;
Zhi CHEN
1
;
Li YANG
3
;
Wen-Jie LU
3
;
Shan-Shan QI
3
;
Ming SUN
3
Author Information
1. Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, Hubei Province, China.
2. Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, Hubei Province, China,E-mail: 22587481@ qq. com.
3. Laboratory of Pediatric Hematology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, Hubei Province, China.
- Publication Type:Journal Article
- Keywords:
acute lymphoblastic leukemia;
hematopoietic stem cell transplantation;
infant
- MeSH:
Male;
Child;
Infant;
Female;
Humans;
Retrospective Studies;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*;
Prognosis;
Hematopoietic Stem Cell Transplantation;
Mutation
- From:
Journal of Experimental Hematology
2023;31(6):1670-1675
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features and outcomes of infants (<1 year old) with acute lymphoblastic leukemia (IALL).
METHODS:The clinical manifestations, laboratory examination results, treatment and prognosis of 18 infants diagnosed with ALL at our department between January 1, 2014 and August 31, 2022 were retrospectively analyzed.
RESULTS:Among the 18 cases of IALL, there were 10 males and 8 females. The median age of patients was 6.5 months old (3 months-11 months old). The median white blood cell count (WBC) was 33.63×109/L ［(3.92-470)×109/L］ at initial diagnosis, including 2 patients with WBC≥300×109/L. Flow cytometric immunophenotyping showed a B-lineage infant ALL in all the 18 patients. Eight of the 18 children had abnormal chromosome karyotype analysis. Fusion gene detection showed 12 KMT2A-rearrangement of 18 patients. 15 patients underwent leukemia related mutation gene screening, among which KRAS, NRAS and FLT3 were the most common mutation genes. 4 patients underwent allogeneic hematopoietic stem cell transplantation and two survived. 14 patients received chemotherapy only and ten survived. The 3-year OS rate was (65.5±11.5)%, while the EFS rate was (46.9±12.3)%.
CONCLUSION:B-cell ALL and KMT2A rearrangement are prevalent in IALL. The therapeutic effect of IALL with standard childhood ALL protocal is similer to international infant specific protocal.
