Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic
10.7499/j.issn.1008-8830.2306093
- VernacularTitle:新型冠状病毒感染流行背景下的儿童多系统炎症综合征
- Author:
Bin ZHOU
1
;
Yu-Kun HUANG
;
Shao-Xian HONG
;
Fu-Yong JIAO
;
Kai-Sheng XIE
Author Information
1. 厦门市儿童医院/复旦大学附属儿科医院厦门分院儿童重症医学中心,福建厦门 361006
- Keywords:
Multisystem inflammatory syndrome in children;
Coronavirus disease 2019;
Severe acute respiratory syndrome coronavirus 2;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(1):98-102
- CountryChina
- Language:Chinese
-
Abstract:
Multisystem inflammatory syndrome in children(MIS-C)is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak.The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms,and severe cases can involve toxic shock and cardiac dysfunction.Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies.The pathogenesis and pathophysiology of MIS-C remain unclear,though immune dysregulation following SARS-CoV-2 infection is considered a major contributing factor.Current treatment approaches for MIS-C primarily involve intravenous immunoglobulin therapy and symptomatic supportive care.This review article provides a comprehensive overview of the definition,epidemiology,pathogenesis,clinical presentation,diagnosis,treatment,and prognosis of MIS-C.
