Considerations on the improvement of height benefit in children with central precocious puberty
10.7499/j.issn.1008-8830.2308078
- VernacularTitle:关于改善中枢性性早熟患儿身高获益的思考
- Author:
Li-Yang LIANG
1
Author Information
1. 中山大学孙逸仙纪念医院儿科神经内分泌科,广东广州 510120
- Keywords:
Precocious puberty;
Height benefit;
Gonadotropin-releasing hormone analog;
Growth hormone;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(1):19-24
- CountryChina
- Language:Chinese
-
Abstract:
With the changes in various factors such as genetics and the environment,the incidence of childhood precocious puberty has been gradually increasing.Improving height is one of the key issues in the clinical management of precocious puberty.Currently,gonadotropin-releasing hormone analogs(GnRHa)remain the preferred treatment for precocious puberty,but their effect on height improvement is influenced by multiple factors,which may result in lower-than-expected height benefits.Combining recombinant human growth hormone(rhGH)therapy with GnRHa treatment is an alternative strategy to enhance the efficacy of GnRHa,but there is still no clear recommendation regarding the timing of their combination.Considering the current status of precocious puberty treatment,it is crucial to reevaluate the effects of GnRHa monotherapy and combination therapy with rhGH on height improvement.This article discusses strategies such as combination therapy indications to guide clinical medication and help children with precocious puberty achieve optimal height benefits.
