The role of natural killer cells in anti-infection and tumor therapy.
- Author:
Xili FENG
1
;
Huihui WANG
1
;
Mengzhu WANG
1
;
Feiyang PU
1
;
Zeyang ZHAO
1
;
Yicong LI
1
;
Xiaoxia MA
1
;
Zhongren MA
2
;
Jianhua ZHOU
3
,
4
Author Information
1. Biomedical Research Center, Northwest Minzu University, Lanzhou 730030; Life Science and Engineering College of Northwest Minzu University, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Lanzhou 730010, China.
2. Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
3. Biomedical Research Center, Northwest Minzu University, Lanzhou 730030; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. *Corresponding author, E-mail: zhoujianhuazjh@
4. com.
- Publication Type:Journal Article
- MeSH:
Humans;
Killer Cells, Natural;
Interferon-gamma;
Apoptosis;
Autoimmune Diseases;
Cytokines
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(10):952-958
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer (NK) cells are an important part of the body's innate immune system. As the first line of defense against pathogens, they need to be transformed into a mature state under the control of various cell signaling molecules and transcription factors to play cytotoxic and immune regulatory roles. Under the interaction of activated receptors and inhibitory receptors, NK cells are activated to perform a direct cell killing effect by secreting perforin and granzyme, or indirectly eliminate pathogenic microorganisms in the body by secreting various cytokines, such as type I and type II interferons. These functions of NK cells play a very important role in antiviral and anti-autoimmune diseases, especially in anti-tumor.
