Relationship between intramuscular fat content in the quadriceps muscle and clinical severity in patients with knee osteoarthritis.
10.12200/j.issn.1003-0034.2023.12.008
- VernacularTitle:股四头肌肌内脂肪含量与膝骨关节炎患者临床严重程度之间的关系
- Author:
Ze-Hua CHEN
1
;
Yi WANG
2
;
Wei-Jian CHEN
2
;
Zhen SHEN
3
;
Xue-Meng XU
4
;
Wen-Gang LIU
4
Author Information
1. Zhuzhou Municipal Orthopaedics Hospital of Traditional Chinese Medicine, Zhuzhou 410000, Hunan, China.
2. The Fifth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong, China.
3. Kunming Hospital of Traditional Chinese Medicine, the Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650011, Yunnan, China.
4. The Fifth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong, China; Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510405, Guangdong, China.
- Publication Type:Journal Article
- Keywords:
Intramuscular fat;
Quadriceps femoris;
knee osteoarthritis
- MeSH:
Male;
Female;
Humans;
Aged;
Middle Aged;
Quadriceps Muscle/physiology*;
Osteoarthritis, Knee/diagnosis*;
Pain;
Body Mass Index;
Muscle Strength/physiology*;
Knee Joint
- From:
China Journal of Orthopaedics and Traumatology
2023;36(12):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore relationship between intramuscular fat content of quadriceps femoris and clinical severity of knee osteoarthritis (KOA).
METHODS:Totally 30 KOA patients were selected from February 2021 to June 2021, including 6 males and 24 females, aged with an average of (64.20±9.19) years old, and body mass index (BMI) was (24.92±3.35) kg·m-2. Patients were divided into relative severe leg (RSL) and relative moderate leg (RML) according to severity of pain on visual analogue scale(VAS). Musculoskeletal ultrasound was used to collect muscle images of quadriceps muscles on both sides of the patient, and Image J was used to analyze echo intensity (EI) of each muscle. Both VAS and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used to assess pain and function. Quadriceps muscle EI on both sides of patients was compared. Pearson correlation analysis was conducted to analyze correlation between quadriceps muscle EI value between RSL and RML, and linear regression was used to analyze relationship between each muscle EI and VAS and WOMA scores of patients.
RESULTS:The EI of RSL lateral vastus lateralis (VL) was 123.78±36.25 and RSL vastus medialis (VM) was 109.46±30.36 which were significantly higher than those of 108.03±31.34 and 93.32±26.04 of RML (P<0.05), but there was no statistical significance in EI values of rectus femoris (RF) on both sides (P>0.05). EI values of VL and VM on both sides were significantly correlated (P<0.05). There was a significant positive correlation between VM EI value and VAS score in RSL and RML (P<0.05). VM EI values in RSL were positively correlated with total WOMAC (P<0.05), and VM VL EI values in RML were positively correlated with total WOMAC score (P<0.05).
CONCLUSION:Intramuscular fat content of quadriceps is closely related to severity of clinical symptoms in KOA patients, and the most obvious one is VM. Therefore, the intramuscular fat content of quadriceps may be an objective indicator to evaluate severity of KOA patients. At the same time, reducing intramuscular fat content of the quadriceps muscle of KOA patients may be a new direction for the prevention and treatment of KOA.
