Research and development practice of traditional Chinese medicine based on network target theory and technology.
10.19540/j.cnki.cjcmm.20230923.701
- Author:
Shao LI
1
;
Bo-Yang WANG
1
;
Liang CAO
2
;
Li-Hao XIAO
3
;
Pan CHEN
1
;
Bo ZHANG
1
;
Xin-Zhuang ZHANG
2
;
Wei XIAO
2
Author Information
1. Institute for TCM-X/Department of Automation, Tsinghua University Beijing 100084, China.
2. National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Lianyungang 222001, China Jiangsu Kanion Pharmaceutical Co., Ltd. Lianyungang 222001, China.
3. Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
artificial intelligence;
multi-modal;
multi-omics;
network pharmacology;
network targets;
research and development of traditional Chinese medicine
- MeSH:
Humans;
Medicine, Chinese Traditional;
Artificial Intelligence;
Drugs, Chinese Herbal/pharmacology*;
Technology;
Research Design
- From:
China Journal of Chinese Materia Medica
2023;48(22):5965-5976
- CountryChina
- Language:Chinese
-
Abstract:
Network targets theory and technology have transcended the limitations of the "single gene, single target" model, aiming to decipher the mechanisms of traditional Chinese medicine(TCM) based on biological network from the perspective of informatics and system. As the core of TCM network pharmacology, with the development of computer science and high-throughput experimental techniques, the network target theory and technology are beginning to exhibit a trend of organic integration with artificial intelligence technology and high-throughput multi-modal multi-omics experimental techniques. Taking the network target analysis of TCM like Yinqiao Qingre Tablets as a typical case, network target theory and technology have achieved the systematic construction, in-depth analysis, and high-throughput multi-modal multi-omics validation of multi-level biological networks spanning from traditional Chinese and Western phenotypes to tissues, cells, molecules, and traditional Chinese and Western medicines. This development helps to address critical issues in the analysis of mechanisms of TCM, including the discovery of key targets, identification of functional components, discovery of synergistic effects among compound ingredients, and elucidation of the regulatory mechanisms of formulae. It provides powerful theoretical and technological support for advancing clinical precision diagnosis and treatment, precise positioning of TCM, and precise research and development of TCM. Thus, a new paradigm of TCM research gradually emerges, combining big data and artificial intelligence(AI) with the integration of human experience and scientific evidence.
