Manufacturing classification system for oral solid dosage forms of traditional Chinese medicines(Ⅲ): classification of granule dissolving behaviors.
10.19540/j.cnki.cjcmm.20230629.301
- Author:
Fei-Yu QI
1
;
Jia-Qi YU
2
;
Wen-Jing LI
1
;
Yong-Kang ZHOU
3
;
Zhi-Qiang ZHANG
3
;
Yan-Jiang QIAO
4
;
Bing XU
4
Author Information
1. Department of Chinese Medicine Informatics, Beijing University of Chinese Medicine Beijing 102488, China.
2. Key Laboratory of Natural Product Chemistry and Functional Molecular Synthesis of Inner Mongolia Autonomous Region, Inner Mongolia Minzu University Tongliao 028000, China.
3. Beijing Key Laboratory of Chinese Medicine Manufacturing Process Control and Quality Evaluation, Beijing Municipal Science & Technology Commission Beijing 102488, China Beijing Tcmages Pharmaceutical Co., Ltd. Beijing 101300, China.
4. Department of Chinese Medicine Informatics, Beijing University of Chinese Medicine Beijing 102488, China Beijing Key Laboratory of Chinese Medicine Manufacturing Process Control and Quality Evaluation, Beijing Municipal Science & Technology Commission Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
classification matrix of dissolving behaviors;
dissolution mechanism;
dissolution rate;
granules;
turbidity curve
- MeSH:
Medicine, Chinese Traditional;
Drugs, Chinese Herbal;
Excipients;
Solubility;
Nonprescription Drugs;
Biological Products
- From:
China Journal of Chinese Materia Medica
2023;48(15):3988-3996
- CountryChina
- Language:Chinese
-
Abstract:
Solubility is an important sensory quality attribute of traditional Chinese medicine(TCM) granules. In this paper, 90 batches of granules(30 batches of TCM formula granules, 30 batches of Chinese patent medicine granules and 30 batches of Japanese Kampo granules) were used as the research objects. The turbidity sensor was used to characterize the turbidity curve of the granule dissolution process. The classification system of granule dissolution behaviors was constructed from three dimensions: dissolution degree, equilibrium time, and dissolution mechanism. According to the equilibrium time, the granule dissolution rates were divided into three categories : faster(<100 s), general(101-300 s) and slow(>301 s). According to the turbidity curve profile, the granule dissolution mechanisms were classified into dissolution-controlled type(α-type), dispersion-controlled type(β-type), and dispersion-controlled type followed by dissolution-controlled type(γ-type). The proportion of TCM formula granules, Chinese patent medicine granules and Japanese Kampo granules with complete dissolution or slight turbidity at the end of dissolution was 46.7%, 96.7%, and 10.0%. The proportion of TCM formula granules, Chinese patent medicine granules, and Japanese Kampo granules with faster dissolution rates(<100 s) was 23.3%, 26.7%, and 40.0%. The average dissolution rate of Japanese Kampo granules was faster than that of TCM formula granules, and it was slightly faster than the average dissolution rate of Chinese patent medicine granules. The dissolution mechanism of Chinese patent medicine granules was mainly α-type, while that of Japanese Kampo granules was mainly β-type, and the three types of dissolution mechanisms of TCM formula granules accounted for a relatively average. The purpose of improving the solubility and dispersion of granules can be achieved by combining the comprehensive application of various functional excipients with the small dosage of Japanese Kampo granules and the wide addition scope of excipients. In the process of transforming TCM compound prescriptions into formulas, there is still much room for innovation in formula excipients and process optimization.
