Solid Tumors With Cold Agglutinins:Report of Two Cases and Literature Review.
10.3881/j.issn.1000-503X.15320
- Author:
Hong-Xiang XIE
1
;
Ru-Hui PAN
2
;
Fei-Fei ZHOU
1
;
Su-Mei WANG
1
;
Su-Feng CHEN
1
;
Wen-Jing CAO
3
;
Jia-Jun JI
4
Author Information
1. Laboratory Medicine Center,Department of Clinical Laboratory,Zhejiang Provincial People's Hospital (Affiliated People's Hospital),Hangzhou Medical College,Hangzhou 310014,China.
2. Department of Clinical Laboratory,Pingdu People's Hospital,Qingdao,Shandong 266700,China.
3. Department of Clinical Laboratory Medicine,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Jinan 250013,China.
4. Department of Clinical Laboratory,Quzhou Hospital of Traditional Chinese Medicine,Quzhou,Zhejiang 324002,China.
- Publication Type:Journal Article
- Keywords:
breast cancer;
cold agglutinins;
ovarian cancer;
solid tumors
- MeSH:
Humans;
Autoantibodies/isolation & purification*;
Female;
Breast Neoplasms/immunology*;
Ovarian Neoplasms/immunology*
- From:
Acta Academiae Medicinae Sinicae
2023;45(4):689-694
- CountryChina
- Language:Chinese
-
Abstract:
Cold agglutinins(CA),autoantibodies against the antigen I or i on the surface of red blood cells,are mainly of IgM class,and the majority have κ light chains.They can lead to red blood cell agglutination at decreased body temperature and are usually associated with infections,drug reactions,autoimmune diseases,and hematological malignancies.However,solid tumors with CA are rare.We reported two cases of CA in the peripheral blood of patients with solid tumors.Peripheral complete blood cell count of the patients at admission showed reduced erythrocyte count and hematocrit,mismatching between erythrocyte count and hemoglobin,abnormally elevated levels of mean corpuscular hemoglobin and mean cell hemoglobin concentration.Peripheral blood smear showed erythrocyte aggregation.After the sample was preheated at 37 ℃ for 30 min,the reversibility of red blood cell aggregation was observed,and the erythrocyte parameters were corrected.
